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TYVASO and TYVASO DPI are approved for the treatment of pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve the ability to exercise.

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WHY TAKE TYVASO? PATIENTS TAKING TYVASO WALKED FARTHER

The 6-minute walk test

PH-ILD can make it difficult for you to walk more than a short distance. The 6-minute walk test (6MWT) can give you a good clue about how much your lung disease could be impacting your ability to stay active. It measures how far you can walk in 6 minutes.

TYVASO has been shown to help patients with PH-ILD be more active

In a 16-week PH-ILD clinical study, 6MWTs were compared for people who took TYVASO and those who took a placebo (an inhaled solution without medicine in it).

At the end of the study, those who took TYVASO improved the distance they could walk in 6 minutes. Those who took a placebo actually experienced a decline in the distance they were able to walk.

*69 feet is about 21 meters.

“After a few weeks, I felt like I had deeper breaths, and I could walk further.*”

— Tina, living with PH-ILD and taking TYVASO
HEAR TINA’S STORY

*Individual results may vary.

REDUCING STRAIN ON THE HEART

TYVASO provides benefits you may not realize

TYVASO may help reduce stress on your heart, measured by a marker called NT-proBNP. High NT-proBNP levels can indicate your heart is under strain, which can make it harder to stay active, exercise, or manage everyday activities. Lower levels may signal your heart is working more efficiently. Your doctor can monitor NT-proBNP levels through a blood test to help ensure TYVASO is working for you.

At week 16 of the clinical study, patients who took TYVASO had less strain on the heart (NT-proBNP decreased by 15%), while patients who took placebo had more strain on the heart (NT-proBNP increased by 46%).

NT-proBNP measures strain on the heart

TYVASO 15% lower NT-proBNP LOWER STRAIN
Placebo 46% higher NT-proBNP HIGHER STRAIN

While treatment can impact your NT-proBNP test results, it is not known how much of an impact those changes could have on your condition.

REDUCING THE RISK OF PH-ILD GETTING WORSE

TYVASO has been shown to reduce disease worsening

In the same study, TYVASO reduced PH-ILD from worsening by 39%.

39% less risk of PH-ILD getting worse

“I find it quick and easy to take each dose.”

— Catherine, living with PH-ILD and taking TYVASO DPI
HEAR CATHERINE’S STORY

Understand the possible side effects and how to manage them.

SEE HOW

Learn how TYVASO can fit your daily routine.

COMPARE DEVICE OPTIONS

IMPORTANT SAFETY
INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
EXPAND

IMPORTANT SAFETY
INFORMATION

COLLAPSE

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at 

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or call 1-800-FDA-1088.

What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI® Inhalation Powder, and additional information at www.TYVASO.com or call 1-844-UNITHER (1-844-864-8437).


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NT-proBNP=N-terminal pro–B-type natriuretic peptide.