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FOR US HEALTHCARE PROFESSIONALS ONLY

TYVASO and TYVASO DPI are approved for the treatment of pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve the ability to exercise.

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UNDERSTANDING PH-ILD

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ABOUT TYVASO

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WHY TAKE TYVASO?

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TAKING TYVASO

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SUPPORT & RESOURCES

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How to Take TYVASO

If your doctor has prescribed or has talked to you about TYVASO, take a moment to learn how it can fit into your daily routine. The more you know about the device and dosing, the more confident you will feel getting started.

Your TYVASO device options

The first step to feeling comfortable with TYVASO is getting familiar with your device. Talk with your healthcare provider to find out which option is best for you.

TYVASO DPI

TYVASO DPI (treprostinil) Inhalation Powder

TYVASO Nebulizer

TYVASO (treprostinil) Inhalation Solution

Portability

Small, portable dry powder inhaler that fits in the palm of your hand

Handheld nebulizer that can be charged overnight for cordless flexibility

Setup

Insert single-dose cartridge and take a breath. Replace inhaler every 7 days

Set up device 1x each morning, clean device 1x each night

Dosing

4x daily
Each dose is inhaled in less than 2 seconds

4x daily
Each session takes about 2-3 minutes

Titration

Most people start with a 16 mcg cartridge and take 1 breath per cartridge, 4x daily. The dose is then typically increased to the next cartridge strength every 1-2 weeks* until they reach a target maintenance dose of 48 to 64 mcg, taken with 1 breath per cartridge, 4x daily

Learn about reaching target maintenance dose

Most people start with 3 breaths, 4x daily, and increase by 1 breath each week to a target maintenance dose of 9-12 breaths, 4x daily

Learn about reaching target maintenance dose
TYVASO DPI

TYVASO DPI (treprostinil) Inhalation Powder

Portability

Small, portable dry powder inhaler that fits in the palm of your hand

Setup

Insert single-dose cartridge and take a breath. Replace inhaler every 7 days

Dosing

4x daily
Each dose is inhaled in less than 2 seconds

Titration

Most people start with a 16 mcg cartridge and take 1 breath per cartridge, 4x daily. The dose is then typically increased to the next cartridge strength every 1-2 weeks* until they reach a target maintenance dose of 48 to 64 mcg, taken with 1 breath per cartridge, 4x daily

Learn about reaching target maintenance dose
TYVASO Nebulizer

TYVASO (treprostinil) Inhalation Solution

Portability

Handheld nebulizer that can be charged overnight for cordless flexibility

Setup

Set up device 1x each morning, clean device 1x each night

Dosing

4x daily
Each session takes about 2-3 minutes

Titration

Most people start with 3 breaths, 4x daily, and increase by 1 breath each week to a target maintenance dose of 9-12 breaths, 4x daily

Learn about reaching target maintenance dose

Your doctor will work with you to reach your target maintenance dose, which is important so that you’ll get the full benefit of the medicine. Titration schedules may vary based on how you tolerate the medicine.

*If the prescribed dose is higher than 64 mcg per treatment session, more than 1 cartridge will be needed per session.

Learn more about managing your side effects.

See How

DPI=dry powder inhaler.

IMPORTANT SAFETY
INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
EXPAND

IMPORTANT SAFETY
INFORMATION

COLLAPSE

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at

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www.fda.gov/MedWatch
or call 1-800-FDA-1088.

What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI™ Inhalation Powder, and additional information at www.TYVASO.com or call 1-877-UNITHER (1-877-864-8437).


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TYVASO and TYVASO DPI are registered trademarks of United Therapeutics Corporation.

All other brands are trademarks of their respective owners. The makers of these brands are not affiliated with and do not endorse United Therapeutics or its products.

© 2022 United Therapeutics Corporation. All rights reserved. US/TYV/0571

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