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SELECT A CONDITION
PATIENT SUPPORT PROGRAM
SELECT A CONDITION
PATIENT SUPPORT PROGRAM
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UNDERSTANDING
PAH

WHAT CAUSES PAH? WHAT IS PROSTACYCLIN? HOW TYVASO CAN HELP

What Causes PAH and Its Symptoms?

People with pulmonary arterial hypertension (PAH) have an imbalance of one or more of 3 natural substances in the body:

When these 3 substances are out of balance, blood vessels in the lungs narrow, requiring the right side of the heart to work even harder to pump blood to the lungs.

This can cause symptoms like shortness of breath and fatigue, which may make it difficult to do daily activities. Because PAH is a progressive disease, you may find yourself becoming less active over time.

Portrait of smiling woman on picnic with her kids Portrait of smiling woman on picnic with her kids

Healthy vessel: Blood can be pumped easily from the heart to the lungs.

Side by side: healthy vessel, vessel with PAH.

Vessel with PAH: Narrow vessels slow down the flow of blood and make the heart work harder to pump blood to the lungs.

Side by side: healthy vessel, vessel with PAH.

There are medicines that treat each of those 3 imbalances, or pathways, associated with PAH. Each PAH medicine targets only one of those pathways.

What Is Prostacyclin? [pra·stuh·si·klin]

Prostacyclin is one of the 3 pathways associated with PAH that helps ensure blood vessels are healthy and stay open. People with PAH may not produce enough prostacyclin in their lungs.

What Is the Function of Prostacyclin?

The function of prostacyclin is to help keep blood flowing through your lungs by:

  • Widening or opening narrow blood vessels
  • Preventing clotting
  • Slowing down the thickening of blood vessels

TYVASO helps replace and mimics the effects of the natural prostacyclin you may be missing.

How Can TYVASO Help Me?

TYVASO may help you do more in your day and do what matters most.

SEE TYVASO BENEFITS

TYVASO Has 2 Device Options

You can take TYVASO in 1 of 2 ways—TYVASO DPI and the TYVASO nebulizer.

SEE TYVASO DEVICES

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You can take it out of your pocket or your purse, put a new cartridge in, take a breath, and you’re on your way.

– TYVASO Patient Discussing TYVASO DPI
Individual results may vary.

IMPORTANT SAFETY
INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
EXPAND

IMPORTANT SAFETY
INFORMATION

COLLAPSE

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at 

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or call 1-800-FDA-1088.

What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI™ Inhalation Powder, and additional information at www.TYVASO.com or call 1-877-UNITHER (1-877-864-8437).


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DPI=dry powder inhaler.

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