PAH Treatment Approaches

Identify Risk and Treat Appropriately to reach Low-Risk Status1,2

PAH treatment algorithm and risk assessmentPAH treatment algorithm and risk assessment

According to the ESC/ERS guidelines, one treatment goal is to achieve a low-risk status.1,2

Assessing risk criteria can help determine whether a patient has a good long-term prognosis and whether treatment changes need to be considered to reach low-risk status.1,2

Achievement/maintenance of an intermediate-risk profile should be considered an inadequate treatment response for most patients with PAH.2

According to 2018 WSPH recommendations, patients who are not achieving low‑risk status should escalate to double, triple, or maximal therapy2§II

Patients with a low-risk status in European and REVEAL PAH registries had a better prognosis.

*Monotherapy may be appropriate for a specific subset of patients.

Patients can be considered for referral for lung transplantation.

Also consider a balloon atrial septostomy.

§Escalation is dependent on the initial background treatment.

IIMaximal therapy is considered triple combination therapy including an SC or an IV PCA.

As demonstrated in observational studies. Additional studies are needed for further validation.

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