Approaches to Help Manage the Most Common Adverse Events
The following approaches to managing adverse events are based on anecdotal evidence cited in Poms et al (2011) and should not be construed as medical advice. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.
Titration schedule can be individualized based on tolerability1:
- If dose of 3 breaths (initial dose) is not tolerated, reduce to 1 or 2 breaths
- If tolerated, dose may be increased by 1 additional breath, instead of by 3 breaths, until the target maintenance dose of 9 breaths (54 mcg) per session is reached
Practical approaches for managing cough2,3:
If a patient is experiencing cough, the first line of action should be to review proper administration technique. Incorrect technique, such as not holding the device level or incorrect placement of the mouthpiece, has been associated with cough and can be corrected with basic retraining.
Additional approaches for managing cough2:
- OTC cough medications
- Analgesic sprays
- Drinking very cold or warm water before a treatment
- Not holding breath once medication is inhaled
- Dose reduction until cough resolves
- Slowing dose up-titration until cough resolves
- Inhaled anticholinergics
- Inhaled steroids
In the TRIUMPH I pivotal trial, there was a discontinuation rate of <1% with Tyvaso due to cough.4
Practical approaches for managing gastrointestinal adverse events2:
- Taking an antidiarrheal
- Eating a small meal before treatment
- Rinsing with water and spitting after treatment
Practical approaches for managing headache2:
- Taking OTC or prescription-strength analgesics
NEXT: Tyvaso has been studied in the long-term treatment of PAH.