- Dosing should be initiated at 3 breaths (18 µg), 4 times daily
- Each treatment session takes ~2 to 3 minutes
- Can be scheduled around daily activities, approximately every 4 hours
Dosing and Titration
Set your patients up for success with Tyvaso
Help patients understand the benefits and risks of therapy.
patients understand the dosing plan
DOSING OF TYVASO1
- Dosing should be titrated to the target dose of 9 breaths (54 µg), 4 times daily
- Patients can titrate 3 breaths per treatment at 1- to 2-week intervals (as tolerated)
- If the titration schedule is not tolerated, consider reducing titration to the previous
dose and resuming with a slower titration
- TYVASO is available as a 2.9-mL ampule containing 1.74 mg of treprostinil (0.6 mg per mL)
- Each breath of TYVASO delivers ~6 µg of treprostinil
- Does not need to be taken with food
ACHIEVABLE TITRATION TO TARGET DOSE WITH TYVASO
In TRIUMPH, TYVASO was initiated at 3 breaths (18 µg) per inhalation session. If clinically tolerated, dosing was increased over the first 2 weeks to reach a target dose of 9 breaths (54 µg), 4 times daily.
- In the TRIUMPH I STUDY, 72% achieved the target dose2
- In the TRIUMPH OLE STUDY, 89% achieved the target dose of 9 breaths, 4 times daily and 42% achieved a dose of 12 breaths, 4 times daily (~288 µg)1*
The prescribing information for TYVASO recommends a maximum dosage of 9 breaths per treatment session, 4 times daily.
HELP PATIENTS ACHIEVE THEIR TARGET DOSE:
9 BREATHS, 4 TIMES DAILY1
Patients can titrate 3 breaths per treatment
at 1- to 2-week intervals (as tolerated).1
Modify titration schedule as needed based on patient tolerance.1
- If starting dose of 3 breaths is not tolerated, reduce to 1 to 2 breaths and increase to 3 breaths as tolerated
- If the titration schedule is not tolerated, consider reducing titration to the previous dose and resuming with a slower titration
for common aes
AE MANAGEMENT APPROACHES
PREPARE YOUR PATIENTS FOR ADVERSE EVENTS
Prepare your patients for common adverse reactions with the following techniques:
MAKING AN ADVERSE EVENTS MANAGEMENT PLAN
Give your patients specific instructions to help manage adverse reactions. Below are some methods to consider for your patients.
The following approaches to managing adverse reactions are based on anecdotal evidence cited in Poms et al (2011)3 and should not be construed as medical advice. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.
Remind patients to talk to you or your staff about any adverse reactions and not to discontinue treatment without your direction.