What is Tyvaso?

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist) or sildenafil (a phosphodiesterase-5 inhibitor). The effects decrease over 4 hours; treatment timing can be adjusted for planned activities.

Studies establishing effectiveness included predominantly patients with NYHA Functional Class III symptoms and etiologies of idiopathic or heritable PAH (56%) or PAH associated with connective tissue diseases (33%).

Tyvaso is an inhaled medication, meaning it is breathed in through the mouth and directly into the lungs. It is a synthetic (man-made) form of prostacyclin called a prostacyclin analogue. Prostacyclin is a chemical made naturally by the body. People with PAH lack enough natural prostacyclin for normal lung function. In the body, Tyvaso mimics some of the effects of natural prostacyclin, helping to open up the arteries in the lungs and make it easier for the heart to pump blood through them. In the clinical trial, patients who added Tyvaso to their oral therapy were able to increase their exercise ability by an average of 20 meters, as shown by their 6-minute walk distance (6MWD).

Tyvaso Patient Brochure

Learn more about adding Tyvaso to your oral therapy.

Why a prostacyclin medication?

PAH is the result of an imbalance of 3 different substances in the body that are responsible for keeping blood vessels open and working properly. One of these substances is prostacyclin.

Different types of treatment target and compensate for these imbalances. So you may benefit from adding Tyvaso, a prostacyclin class medication. Learn more about the different treatment pathways of PAH.

NYHA=New York Heart Association; WHO=World Health Organization.

Next: Why Add Tyvaso?

IMPORTANT SAFETY INFORMATION FOR TYVASO

Before you take Tyvaso, tell your healthcare provider about all of your medical conditions, including if you:

It is important to tell your healthcare provider about all the medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements, as they may affect your use of Tyvaso by increasing the risk of side effects or decreasing effectiveness. Especially tell your healthcare provider if you take any of these medicines:

The most common side effects of Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), and fainting or loss of consciousness. These are not all the possible side effects of Tyvaso. Tell your healthcare provider about any side effects that bother you or do not go away. Your healthcare provider may be able to help you manage the side effects.

INDICATION

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist, (ERA)) or sildenafil (a phosphodiesterase-5 (PDE-5) inhibitor). Your ability to do exercise decreases 4 hours after taking Tyvaso.

The effects of Tyvaso are unknown in patients under 18 years of age.

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Please see the Full Prescribing Information, Patient Package Insert, and the Tyvaso Inhalation System Instructions for Use manual.

For additional information about Tyvaso, visit www.tyvaso.com or call 1-877-UNITHER (1-877-864- 8437).

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

This information is provided for an informational purpose and is not intended as treatment advice. Patients should consult a healthcare professional for treatment advice.