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Find helpful information and videos and support for Tyvaso, a prescription medicine approved for adults with pulmonary arterial hypertension (PAH) (WHO Group 1).

How can I manage side effects?

Help to manage

common Side effects

It is not unusual to experience side effects when taking Tyvaso, and your healthcare team can help you manage them.
We suggest speaking with your healthcare provider in advance about possible common side effects to help you prepare.
For example, many people experience a cough or throat irritation when starting Tyvaso. Your healthcare provider may suggest you keep a throat spray handy to use before starting treatment. Be sure to check out other approaches below.
Of course, if you have any questions, speak with your healthcare provider for advice and talk with your SPS nurse to ensure you are positioning the device properly during your treatment sessions.
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  • Use Tyvaso in a comfortable space where you can easily stand or sit in an upright position.
  • Breathe normally. Don't hold your breath during your treatment sessions.
How do I use the Tyvaso Inhalation System?

Approaches to

managing the most

common Side effects

Cough or throat irritation
The following potential approaches to managing the most common side effects with Tyvaso are based on anecdotal evidence and should not be construed as medical advice. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.
Talk with your doctor or nurse about the things you can do to help manage side effects, such as:
Cough or throat irritation
If you develop a cough or throat irritation
Before treatment
  • Try an over-the-counter cough medicine to help reduce cough
  • Use a throat spray to numb your throat
  • Try drinking cold or hot water
During treatment
  • Avoid holding your breath once you inhale
After treatment
  • Rinse mouth with water (do not swallow the water)
Your doctor may also recommend taking fewer breaths until your cough improves, so make sure you talk to your doctor.
Nausea or
If you experience nausea or diarrhea
  • ︎Eat a small meal before treatment
  • Try taking an over-the-counter antidiarrheal
  • Rinse your mouth with water after treatment
If you experience headaches
  • ︎Use an over-the-counter pain reliever (like acetaminophen)
  • Talk to your doctor to see if slowing the pace at which you increase your dose could help
Make sure to
take all of your
Remember that your physical symptoms may not always reflect whether PAH is progressing or how it is affecting your heart and lungs. Talk to your doctor before changing or stopping your Tyvaso treatment.
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helpful download

Doctor Discussion Guide

Download the Doctor Discussion Guide

Download Prescribing Information and Patient Package Insert

What else can I do?

Important Safety Information for Tyvaso

Before you take Tyvaso, tell your healthcare provider about all of your medical conditions, including if you:

  • Have lung disease, such as asthma or chronic obstructive pulmonary disease (COPD)
  • Have a lung infection
  • Have liver or kidney problems
  • Have low blood pressure
  • Have bleeding problems
  • Are pregnant or plan to become pregnant. It is not known if Tyvaso will harm your unborn baby.
  • Are breast-feeding or plan to breast-feed. It is not known if Tyvaso passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Tyvaso.

Tell your healthcare provider about all the medicines you take , including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tyvaso and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid) or rifampin (Rimactane, Rifadin, Rifamate, Rifater)

What are the possible side effects of Tyvaso?

Tyvaso can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, Tyvaso may lower your blood pressure more
  • Bleeding problems. Tyvaso may increase the risk of bleeding in people who take blood thinners (anticoagulants)

The most common side effects of Tyvaso are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, and diarrhea. These are not all the possible side effects of Tyvaso. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Tyvaso?

Tyvaso (treprostinil) is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH; WHO Group I), which is high blood pressure in the arteries of your lungs. Tyvaso can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking Tyvaso. It is not known if Tyvaso is safe and effective in children under 18 years of age.


Please see the Full Prescribing Information, Patient Product Information, and the Tyvaso Inhalation System Instructions for Use manual.

For additional information about Tyvaso, visit www.tyvaso.com or call 1-877-UNITHER (1-877-864-8437).

This information is provided for an informational purpose and is not intended as treatment advice. Patients should consult a healthcare professional for treatment advice.

The information contained in this section of the site is clinical in nature and specifically created for healthcare professionals. If you are not a US healthcare professional, please click CLOSE to return to the consumer section of the site.
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