Safety and Side Effects

What to tell your healthcare provider before taking Tyvaso

Before taking Tyvaso, tell your doctor about all of your medical conditions, including any of the following:

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Tyvaso and other medicines may affect each other.

Especially tell your doctor if you take any of the following:

Know the medicines you take. Keep a list of them and show it to your doctor and specialty pharmacist when you get a new medicine.

It is not known if Tyvaso is safe or effective in people under 18 years of age.

Possible side effects of Tyvaso

The most common side effects of Tyvaso include the following:

Tyvaso can cause serious side effects, including the following:

Ask your doctor if you are not sure if these apply to you.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Tyvaso. For more information, talk to your doctor or specialty pharmacist.

You may also contact United Therapeutics Corporation at 1-877-864-8437 or via e-mail at drugsafety@unither.com to report adverse events or side effects, or contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Next: Get Answers to Frequently Asked Questions About Tyvaso

IMPORTANT SAFETY INFORMATION FOR TYVASO

Before you take Tyvaso, tell your healthcare provider about all of your medical conditions, including if you:

It is important to tell your healthcare provider about all the medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements, as they may affect your use of Tyvaso by increasing the risk of side effects or decreasing effectiveness. Especially tell your healthcare provider if you take any of these medicines:

The most common side effects of Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), and fainting or loss of consciousness. These are not all the possible side effects of Tyvaso. Tell your healthcare provider about any side effects that bother you or do not go away. Your healthcare provider may be able to help you manage the side effects.

INDICATION

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist, (ERA)) or sildenafil (a phosphodiesterase-5 (PDE-5) inhibitor). Your ability to do exercise decreases 4 hours after taking Tyvaso.

The effects of Tyvaso are unknown in patients under 18 years of age.

TYVISIdtcJUN16

Please see the Full Prescribing Information, Patient Package Insert, and the Tyvaso Inhalation System Instructions for Use manual.

For additional information about Tyvaso, visit www.tyvaso.com or call 1-877-UNITHER (1-877-864- 8437).

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

This information is provided for an informational purpose and is not intended as treatment advice. Patients should consult a healthcare professional for treatment advice.