Frequently Asked Questions About Tyvaso
Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of the lungs. People living with PAH have too little prostacyclin in their bodies. Tyvaso is a prostacyclin class therapy that mimics the effects of the natural prostacyclin in the body, helping to keep the pulmonary arteries open and working properly.
Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist [ERA]) or sildenafil (a phosphodiesterase-5 [PDE-5] inhibitor). The effects decrease over 4 hours; treatment timing can be adjusted for planned activities.
Tyvaso must be prescribed by your doctor and can be taken only by using the Tyvaso Inhalation System.
Prostacyclin class therapy is an established treatment option for pulmonary arterial hypertension (PAH). It mimics some of the effects of prostacyclin, a substance naturally produced by the body to help keep blood vessels open and working properly.
The Tyvaso Inhalation System is a portable, handheld device that delivers Tyvaso directly to your lungs. The system consists of the following items:
- Daily-use plastic ampules. One ampule provides a full day's supply of medication
- A lightweight, portable device with plastic accessories for inhaling Tyvaso. The device comes with a rechargeable battery and carrying case
You need a prescription from your doctor to receive both Tyvaso and the Tyvaso Inhalation System.
Because Tyvaso requires training prior to use, your doctor or Specialty Pharmacy Services (SPS) provider will teach you how to use the Tyvaso Inhalation System once you have been prescribed Tyvaso.
- Do not start treatment with Tyvaso until you have completed your training
- Make sure you understand all of the directions
- Always ask your doctor or SPS provider if you are unsure of anything you have been taught
- Learn more about using the Tyvaso Inhalation System from the Instructions for Use manual. The manual is included as part of the initial shipment from your SPS provider and may also be downloaded by clicking here
Before you begin therapy with Tyvaso, you’ll receive a Tyvaso Inhalation System Starter Kit from your Specialty Pharmacy Services (SPS) provider. It includes the following:
- 2 Tyvaso Inhalation Systems
- 2 sets of accessories
- A 28-day supply of Tyvaso
- A carrying case
- Instructions for Use manual
- 3 power supply options (battery, wall plug-in, and car plug-in)
- Getting Started With Tyvaso folder. The folder includes several important items: the Tyvaso Treatment Tracker (also available in Spanish) to help you manage your daily treatment sessions; the Tyvaso Patient Brochure (also available in Spanish); an instructional DVD titled, "Getting Started with Tyvaso"; and an enrollment form for the Tyvaso Support Program. Enroll now
Each month, you’ll receive a refill kit from your SPS provider that includes the following:
- A new set of accessories
- A 28-day supply of Tyvaso
- A new Tyvaso Treatment Tracker
The Instructions for Use manual will tell you all you need to know to properly assemble, use, care for, and troubleshoot your Tyvaso Inhalation System.
Here are some key things to remember:
- Once-daily cleaning: Clean the accessories once a day with mild soapy water. Allow them to air dry
- Rechargeable battery: Keep your portable battery charged in case it is immediately needed. Always have your AC wall plug available for backup if the battery is not charged
- Storage: Use the carrying case to house the inhalation system between treatment sessions and at the end of each day
- Weekly cleaning: Once each week, use a clean cloth to wipe the interior of the device chamber. Do not soak the device in water or put it in a dishwasher
- Accessory replacement: Each month, your Specialty Pharmacy Services (SPS) provider will automatically send you a new set of accessories for your Tyvaso Inhalation System
- Device replacement: Your inhalation device will be replaced automatically every 2 years through your SPS provider
Your Specialty Pharmacy Services (SPS) provider will replace your device automatically every 2 years. Should your device need replacing before then, please contact your SPS provider.
Tyvaso and the Tyvaso Inhalation System are available only through the following SPS providers:
Each month, your Specialty Pharmacy Services (SPS) provider will send you a 28-day supply of Tyvaso, along with a kit containing a new set of accessories for your Tyvaso Inhalation System.
Don't hesitate to contact your SPS provider if you have any questions about taking Tyvaso, operating the Tyvaso Inhalation System, or if you need more medication.
You’ll continue receiving your monthly supply of Tyvaso for as long as your doctor continues to prescribe the treatment.
Tyvaso is supplied in plastic ampules packaged in a light-protective foil pouch. Ampules of Tyvaso are stable until the date indicated when stored in the unopened foil pouch at 25°C (77°F), with excursions permitted to 15°C to 30°C (59°F to 86°F). Each pouch contains 4 ampules, and each ampule provides a full day's supply of Tyvaso. Once an ampule is opened and the inhalation solution is put in the medicine cup, it should remain in the device no more than 24 hours; any remaining solution should be discarded at the end of the day. Once a pouch is opened, the remaining ampules inside the pouch must be used within 7 days. Unopened ampules should be stored in the foil pouch, protected from light. Tyvaso does not need to be refrigerated.
The most common side effects seen with Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of your face and neck (flushing), and fainting or loss of consciousness. Tyvaso may cause other serious side effects, including the following:
- Tyvaso increases the risk of bleeding, particularly in people who take blood thinners (anticoagulants)
- If you have low blood pressure, Tyvaso may lower your blood pressure further
Tyvaso is the only inhalable PAH treatment studied solely as an add-on therapy to be used in addition to oral medications. It was studied with the medication bosentan (an endothelin receptor antagonist [ERA]) or sildenafil (a phosphodiesterase-5 [PDE-5] inhibitor).
Since Tyvaso may interact with certain medications, tell your doctor if you’re taking any of the following:
- Water pills (diuretics)
- Medicines that decrease blood clotting
- Medicines used to treat high blood pressure or heart disease
- Gemfibrozil (Lopid®), which is used to lower high blood cholesterol
- Rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®), an antibiotic used to treat infections
Be sure to make a list of all the medicines (prescription and over the counter), vitamins, and herbal supplements you take routinely or even occasionally. Update the list as needed, keep it with you, and show it to your doctor or Specialty Pharmacy Services provider.