About PAH

Pulmonary arterial hypertension (PAH) is high blood pressure in the arteries of the lungs. It is the result of changes in cells that line the arteries in the lungs. Excess cells and platelets build up, causing the arteries to narrow, raising pressure and decreasing blood flow from the heart to the lungs. The right side of the heart then has to pump harder to move blood into the lungs. Over time, this causes the right side of the heart to enlarge and weaken, ultimately causing heart failure.

When pulmonary arteries become narrow, less blood gets pumped into the lungs to pick up oxygen to carry to the rest of the body. This causes the symptoms of PAH.


Next: Learn About the Symptoms of PAH

IMPORTANT SAFETY INFORMATION FOR TYVASO

Before you take Tyvaso, tell your healthcare provider about all of your medical conditions, including if you:

It is important to tell your healthcare provider about all the medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements, as they may affect your use of Tyvaso by increasing the risk of side effects or decreasing effectiveness. Especially tell your healthcare provider if you take any of these medicines:

The most common side effects of Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), and fainting or loss of consciousness. These are not all the possible side effects of Tyvaso. Tell your healthcare provider about any side effects that bother you or do not go away. Your healthcare provider may be able to help you manage the side effects.

INDICATION

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist, (ERA)) or sildenafil (a phosphodiesterase-5 (PDE-5) inhibitor). Your ability to do exercise decreases 4 hours after taking Tyvaso.

The effects of Tyvaso are unknown in patients under 18 years of age.

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Please see the Full Prescribing Information, Patient Package Insert, and the Tyvaso Inhalation System Instructions for Use manual.

For additional information about Tyvaso, visit www.tyvaso.com or call 1-877-UNITHER (1-877-864- 8437).

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

This information is provided for an informational purpose and is not intended as treatment advice. Patients should consult a healthcare professional for treatment advice.