What Is
Tyvaso?

How to Use
Tyvaso

How to Get
Tyvaso

Specialty
Pharmacy Service

What Is
PAH?

Living
with PAH

Resources

Patient
Assistance

Helpful Links

There are a lot of online resources available for people living with pulmonary arterial hypertension (PAH). The links below provide additional education, resources and support.

LivingPAH.com

Living PAH is dedicated to empowering people who are living with PAH and their loved ones by providing the most up-to-date information on the disease and treatment, along with a variety of support services, to help manage the challenges of living with PAH.

For more information, visit www.livingpah.com.

Caring Voice Coalition

Caring Voice Coalition (CVC) is an independent, national, nonprofit organization dedicated to helping patients affected by chronic disease. CVC supports patients in need through co-pay and premium assistance.

CVC’s Financial Assistance Program may pay for a portion or all of a patient’s costs under the patient’s health insurance plan.

Financial assistance is available for eligible patients who cannot afford:

Insurance premiums
Insurance co-payments
Medicare prescription co-payments

For more information on CVC’s Financial Assistance Program, call 1-888-267-1440 or visit www.caringvoice.org.

Pulmonary Hypertension Association (PHA)

PHA is a leading community-based organization for patients with PAH. Its mission is to find ways to prevent and cure PAH, while providing hope to the community of affected individuals. To that end, the PHA offers the following services:

Support groups, both local and online
Educational programs for patients and families
Tips on getting the most from your health insurance program
Advocacy programs for lobbying members of Congress
Updates on new developments in the field of PAH

For more information, visit www.PHAssociation.org.

National Heart Lung and Blood Institute (NHLBI)

NHLBI is part of the National Institutes of Health (NIH), the agency of the U.S. Department of Health and Human Services that is largely responsible for conducting medical research. The NHLBI website has easy-to-understand information about various diseases that affect the heart and lungs. To learn more about PAH, visit www.nhlbi.nih.gov and search for PAH.

American Heart Association (AHA)

Founded in 1924, the AHA is the nation’s oldest and largest voluntary health organization dedicated to building healthier lives, free of heart disease and stroke. To help prevent, treat and defeat these diseases—America’s #1 and #3 killers—the AHA funds cutting-edge research, conducts lifesaving public and professional educational programs, and advocates for public health. To learn more, or to join the AHA in helping all Americans, call 1-800-AHA-USA1.

For more information, visit www.americanheart.org.

Adult Congenital Heart Association (ACHA)

ACHA is a nonprofit organization seeking to improve the quality of life and extend the lives of people with congenital heart defects through education, outreach, advocacy, and promotion of research.

For more information, visit www.achaheart.org.

Indication

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist) or sildenafil (a phosphodiesterase-5 inhibitor). The effects decrease over 4 hours; treatment timing can be adjusted for planned activities.

Studies establishing effectiveness included predominately patients with NYHA Functional Class III symptoms and etiologies of idiopathic or heritable PAH (56%) or PAH associated with connective tissue diseases (33%).

Important Safety Information for Tyvaso

Tyvaso is breathed in (inhalable) through your mouth into your lungs. Tyvaso should only be used with the Tyvaso Inhalation System
The effects of Tyvaso are unknown in patients with lung disease (such as asthma or chronic obstructive pulmonary disease) and in patients under 18 years of age
If you have low blood pressure, Tyvaso may cause symptomatic hypotension (low blood pressure)
Because Tyvaso reduces the ability of your blood to clot (coagulate), it may increase your risk for bleeding if you are taking blood thinners (anticoagulants), such as warfarin or heparin
The use of Tyvaso with diuretics (water pills), antihypertensives (medications used to treat high blood pressure or heart disease), or other vasodilators (medications that lower blood pressure) may increase your risk for hypotension (low blood pressure)

Other medical conditions and medicines may affect your use of Tyvaso by increasing the risk of side effects or decreasing effectiveness. It is important to tell your doctor about your medical conditions and any medicines you may be taking, including:

If you are taking gemfibrozil (for high cholesterol) or rifampin (for infection), your Tyvaso dosage may need adjustment
If you have liver or kidney problems, your ability to tolerate Tyvaso may be affected
If you are pregnant, breast-feeding, or planning to become pregnant, talk with your healthcare provider about whether you should take Tyvaso

The most common side effects of Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), and fainting or loss of consciousness. These are not all the possible side effects of Tyvaso. Tell your doctor about any side effects that bother you or do not go away. Your doctor may be able to help you manage the side effects.

For more information about Tyvaso, please see the Full Prescribing Information, Patient Package Insert, and the Tyvaso Inhalation System Instructions for Use Manual. Questions? Call the Customer Service Line at 1-877-UNITHER (1-877-864-8437).