SUPPORTABLE

Important Safety Information Full Prescribing Information Patient Package Insert Instructions For Use

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Support services for patients taking Tyvaso® are here to help manage the daily challenges of living with pulmonary arterial hypertension (PAH).

Living PAH

Living PAH Is in Your Corner

Living PAH is dedicated to empowering people who are living with PAH and their loved ones by providing the most up-to-date information on the disease and treatment, along with a variety of support services, to help manage the challenges of living with PAH. Living PAH is an amazing community that has support and resources for any part of your journey with PAH.

Check out the resources Living PAH has available to you:

  • Patient PHorums
    Join an informational seminar in your area
  • PEER Network
    Talk one-on-one with another PAH patient through secure, confidential phone calls or emails
  • Healthy Recipes
    Find healthy, low-sodium recipes to enjoy
  • Patient Call Center
    The Living PAH Call Center is accessible 24 hours a day, 7 days a week. Operators are on hand from 7:00 a.m. to 7:00 p.m. Central time and Registered Nurses from 9 a.m. to 5 p.m. Central time to answer your questions about PAH, United Therapeutics treatments and Living PAH. The Patient Call Center number is 1-877-948-9137

To learn more about Living PAH support and available resources, visit www.livingpah.com.

Questions? Call the Living PAH call center for answers. Operators and Registered Nurses are available to answer general questions at 1-877-948-9137.

Indication

Tyvaso is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of your lungs. Tyvaso can improve exercise ability in people who also take bosentan (an endothelin receptor antagonist) or sildenafil (a phosphodiesterase-5 inhibitor). The effects decrease over 4 hours; treatment timing can be adjusted for planned activities.

Studies establishing effectiveness included predominately patients with NYHA Functional Class III symptoms and etiologies of idiopathic or heritable PAH (56%) or PAH associated with connective tissue diseases (33%).

Important Safety Information for Tyvaso

  • Tyvaso is breathed in (inhalable) through your mouth into your lungs. Tyvaso should only be used with the Tyvaso Inhalation System
  • The effects of Tyvaso are unknown in patients with lung disease (such as asthma or chronic obstructive pulmonary disease) and in patients under 18 years of age
  • If you have low blood pressure, Tyvaso may cause symptomatic hypotension (low blood pressure)
  • Because Tyvaso reduces the ability of your blood to clot (coagulate), it may increase your risk for bleeding if you are taking blood thinners (anticoagulants), such as warfarin or heparin
  • The use of Tyvaso with diuretics (water pills), antihypertensives (medications used to treat high blood pressure or heart disease), or other vasodilators (medications that lower blood pressure) may increase your risk for hypotension (low blood pressure)

Other medical conditions and medicines may affect your use of Tyvaso by increasing the risk of side effects or decreasing effectiveness. It is important to tell your doctor about your medical conditions and any medicines you may be taking, including:

  • If you are taking gemfibrozil (for high cholesterol) or rifampin (for infection), your Tyvaso dosage may need adjustment
  • If you have liver or kidney problems, your ability to tolerate Tyvaso may be affected
  • If you are pregnant, breast-feeding, or planning to become pregnant, talk with your healthcare provider about whether you should take Tyvaso

The most common side effects of Tyvaso are coughing, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), and fainting or loss of consciousness. These are not all the possible side effects of Tyvaso. Tell your doctor about any side effects that bother you or do not go away. Your doctor may be able to help you manage the side effects.

For more information about Tyvaso, please see the Full Prescribing Information, Patient Package Insert, and the Tyvaso Inhalation System Instructions for Use Manual. Questions? Call the Customer Service Line at 1-877-UNITHER (1-877-864-8437).

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